Christian McCaffrey injury update: 49ers star limited in practice, odds shift in Seahawks’ favor

San Francisco 49ers fans received unwelcome news just days before the season opener. Star running back Christian McCaffrey, widely regarded as the team’s offensive engine, was added to the injury report with a calf issue. The setback, announced Thursday, comes after an offseason where McCaffrey appeared fully healthy and primed for a bounce-back year. His availability against the Seattle Seahawks now hangs in the balance.Christian McCaffrey’s durability has been a lingering storyline throughout his career. Entering his ninth NFL season, the 29-year-old has experienced more than his share of setbacks. Last year, Achilles tendinitis sidelined him for eight games before a knee injury in Week 13 ended his campaign after only four appearances. That came just one season removed from a spectacular 1,459-yard performance that earned him First-Team All-Pro honors.This summer brought optimism. McCaffrey looked sharp during voluntary workouts and participated in training camp without restrictions. Fantasy football managers and oddsmakers alike expected him to carry a heavy load for San Francisco’s playoff push. But Thursday’s report reignited worries about whether his body can endure another grueling season.The timing of McCaffrey’s injury immediately impacted betting markets. FanDuel Sportsbook trimmed the 49ers’ line from -2.5 to -1.5 against the Seahawks, underscoring just how central he is to San Francisco’s success.Fortunately for the 49ers, they bolstered their backfield depth in the offseason. Newly acquired Brian Robinson Jr., who rushed for 799 yards and eight touchdowns with Washington last year, could see an expanded role if McCaffrey is limited. Second-year back Isaac Guerendo, who contributed 420 yards and four scores as a rookie, also provides insurance.Still, neither option replicates the unique skill set McCaffrey brings — his blend of vision, burst, and pass-catching ability transforms the 49ers’ offense when he is on the field. As head coach Kyle Shanahan prepares for Sunday, all eyes will be on Friday’s practice report for clarity on McCaffrey’s status.The 49ers begin 2025 with one of the league’s most favorable schedules, but injuries have a way of rewriting even the brightest projections. For now, the hope in San Francisco is simple: that Christian McCaffrey’s latest setback is minor and not a preview of another frustrating season.Also Read: Eagles surprise fans with risky inactive list against Cowboys, sparking questions ahead of season’s opening night clash