Blood cancer impairs the bone marrow's ability to produce healthy blood cells. While these cancers are serious, the growing knowledge in medical science has improved survival rates. Understanding the causes, risk factors, symptoms, and treatment options is crucial for effective management and care.
Regular check-ups and medical screening allow for early detection of the disease. With multiple treatment options including chemotherapy, radiation therapy, and stem cell transplantation, blood cancers can often be cured or at least put in remission. These successful outcomes can reduce suffering, improve quality of life, and extend survival rates. Early detection and early treatment are essential for good outcomes. It is important to monitor progress and track response to treatment.
What is blood cancer?
Blood cancer, also known as hematologic cancer, occurs when your bone marrow produces abnormal blood cells that don't function properly. These cells overcrowd the healthy ones, disrupting normal blood cell production. The bone marrow stem cells mature into the three main types of blood cells:
Red blood cells carry oxygen throughout the body
White blood cells fight infections
Platelets control bleeding
While blood cancer is a serious diagnosis, advancements in medical science have improved survival rates.
Symptoms of blood cancer
According to the Cleveland Clinic, the following symptoms can also occur with non-cancerous conditions.
- Fatigue and shortness of breath
- Swollen lymph nodes and frequent infections
- Bone pain and joint pain
- Drenching night sweats and persistent fever
- Enlarged liver or spleen
- Unexplained weight loss
- Unusual bruising or bleeding (including tiny red skin spots or purplish patches)
If you experience persistent symptoms lasting more than a few weeks, consult a healthcare provider for proper evaluation and diagnosis.
How is blood cancer caused?
- Blood cancer begins when DNA mutations occur in blood cells, disrupting normal cell function.
- DNA provides instructions for cell growth, division, and death
- When DNA mutations give instructions, abnormal blood cells develop and multiply rapidly, outpacing normal cells.
- As a result, the bone marrow becomes crowded with abnormal cells, leading to a decline in normal blood cell production.
- This ultimately impairs the body's ability to perform essential functions, such as fighting infections, carrying oxygen, and controlling bleeding
Risk factors of blood cancer
- Age: The Risk of blood cancer increases with age
- Sex: Blood cancer is more common in males
- Smoking: Smoking history or secondhand smoke exposure may increase risk
- Toxic chemical exposure: Long-term exposure to benzene and formaldehyde, often in manufacturing industries
- Previous cancer treatment: Chemotherapy or radiation therapy may increase the risk
- Family history: Some blood cancers may run in family members
- Certain conditions: Autoimmune diseases, chronic inflammation, and genetic disorders may increase the risk
Can the risks of blood cancer be lowered?
While blood cancer isn't entirely preventable, you can reduce your risk by avoiding certain factors, such as smoking. Minimising exposure to toxic chemicals and managing underlying health conditions may also help. However, many cases of blood cancer occur without known risk factors, so regular health check-ups and screenings are essential
Main types of blood cancer
Leukemia: The most common blood cancer in the US and childhood cancer, starting in the bone marrow and affecting immature white blood cells.
Lymphoma: Cancer of the lymphatic system, starting in lymphocytes (white blood cells), and forming tumors in lymph nodes. Subtypes include Hodgkin and non-Hodgkin lymphoma.
Myeloma: Starts in the bone marrow, affecting plasma cells (white blood cells), with multiple myeloma being the most common subtype.
Rarer forms of blood cancer:
Myeloproliferative Neoplasms (MPN): Bone marrow overproduces blood cells.
Myelodysplastic Syndromes (MDS): Bone marrow produces abnormal blood cells that don't develop fully.
These blood cancers vary in their characteristics, symptoms, and treatment options. Understanding the specific type and subtype is crucial for effective management and care
Diagnosing blood cancer
To diagnose blood cancer, according to the Cleveland Clinic, doctors typically follow these steps:
- Medical history and physical exam: Discuss symptoms and medical history, followed by a thorough physical examination.
- Blood tests: Conducting tests like Complete Blood Counts (CBC) to check for abnormal blood cell levels and blood chemistry tests to detect cancer-related proteins.
- Imaging tests: Using CT scans, MRIs, and PET scans to detect cancer signs in specific body parts.
- Bone marrow biopsy: Removing a bone marrow sample to analyze abnormal cell presence and genetic changes driving cancer growth.
These tests help doctors determine the presence and type of blood cancer, guiding effective treatment planning
Treatment procedures to treat blood cancer
Chemotherapy: Kills cancer cells to slow or eliminate the disease, using different drugs for various blood cancers.
Radiation therapy: Damages abnormal cell DNA to prevent replication, often used for palliative care or combined with other treatments.
Immunotherapy: Enhances the immune system's ability to fight cancer, including monoclonal antibodies and CAR T-cell therapy.
Targeted therapy: Targets cancer cell weaknesses related to genetic mutations.
Stem cell transplants:
- Autologous: Collects and reinfuses a patient's healthy stem cells after chemotherapy.
- Allogeneic: Replaces damaged bone marrow with healthy donor stem cells.